新型丝氨酸蛋白酶Matriptase在膀胱移行细胞癌中的表达及意义

Expression of Matriptase in Bladder Transitional Cell Carcinoma and Its Significance

【目的】检测新型丝氨酸蛋白酶(Matriptase)在膀胱移行细胞癌(BTCC)中的表达,探讨与BTCC临床病理参数间的关系及其临床意义。【方法】应用免疫组化技术检测Matriptase在BTCC及正常膀胱组织中的表达,并结合临床病理资料分析。【结果】Matriptase在BTCC及正常膀胱黏膜中均有表达;在BTCC中的表达阳性率明显低于正常膀胱组织,差异有统计学意义(P<0.05);膀胱肿瘤中低分化组表达明显低于高分化组,组间差异有统计学意义(P<0.05);不同临床分期、淋巴结转移组间差异无统计学意义(P>0.05)。【结论】Matriptase在BTCC中的表达与促分化有关,可能是一种分化程度的指标。

[Objective] To investigate the expression of a new serine protease Matriptase in bladder transitional cell carcinoma（BTCC） and its clinical significance.[Methods] Expression of Matriptase in specimens of bladder transitional cell carcinoma and normal bladder tissues was detected by SP of immunohistochemistry.The clinicopathological data were also analyzed.[Results]The expression of Matriptase was observed in both normal and tumor tissues of bladder.The protein level of Matriptase was significantly higher in normal bladder tissues than that in BTCC tissues（P〈0.05）.The protein level of Matriptase was significantly higher in high-grade tissues than that in moderate and low-grade tissues（P〈0.05）.The expression of Matriptase showed no difference in clinical stages.[Conclusion] Matriptase protein in BTCC may be an indication of differentiation.