缺血性心力衰竭中医证候与心功能相关性的临床研究

Association between Ischemic Heart Failure in TCM Syndromes and Cardiac Function

目的观察缺血性心力衰竭常见中医证候要素、证候分型与心功能的相关性。方法采用横断面调查的流行病学方法,收集208例IHF患者临床资料,总结中医证候特点,运用医学统计方法,分析中医证候与纽约心脏病学会(NYHA)心功能分级、心功能指标及N端前脑钠素(NT-proBNP)的相关性。结果证候要素、证候分型不同患者的NYHA心功能分级有统计学意义(P<0.01),阳虚、水饮证、心肾阳虚型、阳虚水泛型左室射血分数(LVEF)<50%,与其他证型比较有统计学意义(P<0.01),NT-proBNP高于其他证型,差异有统计学意义(P<0.05或P<0.01)。结论缺血性心力衰竭患者中医证候与心功能具有明显相关性。

Objective To investigate the relation between ischemic heart failure （IHF） in TCM syndromes and heart function. Methods A cross - sectional epidemiological survey was carried out and data of 208 patients （pts） with IHF were collected. The rela-tion between TCM syndromes and NYHA cardiac function,heart function index of echocardiogram and NT- proBNP were investigated. Results NYHA cardiac function were different based on different elements and factors of TCM syndromes significantly （P〈0.01）. LVEF in pts with Yang deficiency and excessive fluid, Yang deficiency of heart and kidney, edema due to Yang deficiency was less than 50% compared with other syndrome factors （P〈0.01）. NT- proBNP of foregoing syndrome factors was higher than that in other syndrome factors （P〈0.05 or P〈0.01）. Conclusion TCM syndrome factors in pts with IHF was related with cardiac function.