益气凉血解毒类中药对拉米夫定诱发乙肝病毒YMDD变异的干预作用

Study on interference effect of Chinese drugs of Yiqi Liangxue Jiedu on YMDD variation of HBV induced by lamivudine

目的:观察益气凉血解毒类中药对慢性乙型病毒性肝炎抗病毒治疗及其耐药株发生率的影响。方法:选择慢性乙型病毒性肝炎患者138例,随机分为3组,分别予以口服拉米夫定、拉米夫加益气凉血解毒类中药和单纯益气凉血解毒类中药治疗,疗程均为12个月,分别观察肝功能、HBVM指标、HBV-DNA、YMDD和临床症状的变化。结果:3组在治疗后临床症状均明显改善,ALT、AST、HBV-DNA均降低,有明显统计学意义(P<0.05)。治疗后3组间各指标无明显差异(P>0.05)。结论:益气凉血解毒类中药可以对拉米夫定诱发的乙型肝炎病毒YMDD变异起到明显的抑制作用,且对慢性乙型病毒性肝炎有明显疗效。

Objective： To investigate the effect of Chinese drugs of Yiqi Liangxue Jiedu on chronic hepatitis B and the incidence of drug-resistant strains. Methods： 138 patients with chronic hepatitis B were divided randomly into 3 groups： oral administration lamivudine group, oral administration lamivudine and Chinese herb of Yiqi Liangxue Jiedu group, and oral administration Chinese drugs of Yiqi Liangxue Jiedu group. The treatment course of 3 groups was 48 weeks. Liver function, HBV-DNA and variation of YMDD were observed after 12weeks, 24 weeks, 36 weeks and 48weeks. Results： In each group, the subjective symptoms improved obviously （P〈0.05）, and ALT, AST, HBV-DNA decreased significantly after treatment （P〈0.05）, while the difference among these groups were not significant （P〉0.05）. Conclusion： It is indicated that Chinese herb of Yiqi Liangxue Jiedu can inhibit the variation of YMDD induced by lamivudine therapy and has definite effect on patients with chronic hepatitis B.