血浆同型半胱氨酸与高血压病中医证型关系的研究

Study on relationship between TCM syndrome types and plasma homocysteine in patients with essential hypertension

目的:探讨血浆同型半胱氨酸(HCY)与高血压病(EH)中医证型的关系。方法:将343例患者按中医辨证分为肝火亢盛、阴虚阳亢、阴阳两虚、气虚痰浊4型,用荧光偏振免疫法检测EH患者与健康对照组血浆HCY水平。结果:EH患者血浆HCY水平显著高于健康对照组(P<0.01),EH患者中医各证型血浆HCY水平均显著高于键康对照组,依次为P<0.05或P<0.01,气虚痰浊型血浆HCY水平显著高于肝火亢盛型、阴虚阳亢型及气虚痰浊型(P<0.05或P<0.01)。结论:血浆HCY水平异常增高是EH的重要危险因素之一,EH患者血浆HCY水平显著增高可作为中医证型气虚痰浊型的辨证指标。

Objective： To study the relation between plasma homocysteine （HCY） and TCM syndrome types in essential hypertension （EH） patients. Methods： 343 cases of essential hypertension were devided into following 4 syndromes： hyperactivity of liver-fire, hyperactivity of yang due to yin deficiency, deficiency of both yin and yang, qi-deficiency and staganation of phlegm. Plasma homocysteine in patients of EH and normal person were detected with fluorescenoe polarization immunoassay （FP1A）. Results： HCY level in patients of EH was significantly higher than that of healthy controls （P〈0.01）, HCY level in the hypertensive patients with different syndromes of TCM was significantly higher than that of healthy controls （P〈0.05 or P〈0.01）. Conclusion： Abnormal increase of plasma HCY level is an important risk factor of EH, the significant increase of plasma HCY level is a Chinese medical pattern identification index of the patients with qi-deficiency and staganation of phlegm.