不同地区及途径HIV／HCV合并感染状况调查

Investigation of HIV co-infection with hepatitis C virus through different infectious routes

目的了解中国不同地区、不同感染途径人类免疫缺陷病毒(HIV)合并丙型肝炎病毒(HCV)感染情况。方法调查既往有偿采供血173人、静脉吸毒89人和性途径194人的HIV感染者人口学、感染途径、献血/卖血史、吸毒史、同性性行为史、婚外性行为史及检测HCV-IgG抗体。结果总HCV-IgG抗体阳性率63.24%;既往有偿采供血、静脉吸毒和性途径HIV感染者HCV-IgG阳性率分别为95.40%,98.88%,18.04%;合并HCV感染的危险因素为既往有偿采供血(OR=89.84,95%CI=40.31～200.24)和静脉吸毒感染(OR=363.72,95%CI=48.90～∞);河南省和新疆维吾尔自治区性途径合并HCV感染率分别为19.81%,25%,明显高于辽宁省的2.94%(P<0.01)。结论HIV感染者总HCV-IgG阳性率显著高于我国一般人群。经性接触感染HIV者的HCV感染率显著低于经静脉吸毒和经血途径,经吸毒感染HIV和经既往有偿采供血感染HIV是感染HIV的危险因素。经性感染HIV由于地域和性伴不同,HCV合并感染率差异有统计学意义。

Objective To investigate HIV co-infection with hepatitis C virus through different infectious routes in different regions in China. Methods 174 HIV-1-infected former plasma donors（FPD）, 89 HIV-1-infected injected drug users （IDU） and 194 HIV-1-infeeted heterosexuals were enrolled. Demology, infectious route, data of plasma donor, injected drug, homosexual, heterosexual were investigated and HCV IgG were measured. Results The total posotive rate of HCV-IgG was 63.24%, and 95.40% in FPD, 98.88% in IDU, 18.04% in heterosexual, respectively. The risk factor of HIV co- infected with HCV were FPD（ OR = 89.84, 95 % CI = 40.31 - 200.24） and IDU（ OR = 363.72, 95 % CI = 48.90 - ∞ ）. The infected rate of co-infection in Henan and Xinjiang province were 19.81%, 25.00 %, it was more higher than 2.94 % in Liaoning province. Conclusion The total posotive rate of HCV-IgG in HIV infection indivduals was higher than common population. The rate of HCV infected in heterosexual was lower than that of FPD and IDU. FPD and IDU were risk factor of HIV co-infection with HCV. The different region and sex parther resulted in difference of HCV co-infection.