摘要
基因治疗是指将人的正常基因或有治疗作用的基因导入人体靶细胞以纠正基因的缺陷或发挥治疗作用,因此它可用来治疗一些后天性和遗传性疾病,其成功与否的关键是载体。目前应用的载体主要有包括病毒和非病毒载体,但在基因治疗中应用最为广泛的载体是病毒载体。本文就近年来病毒载体系统在基因治疗中的应用及其改进等方面的研究进行综述。
Gene therapy relies on the delivery of normal gene or medicative gene into human cells, it may correct the gene defects or play role in treatment of diseases. It is a promising treatment for several acquired and inherited diseases, but their success is depends on vector. At present, the main vectors are virus vectors and non-virus vectors, but viral vectors are the most widely vectors used in gene therapy. This article focused on recent application and improvement of virus vectors in gene therapy.
出处
《医学综述》
2008年第24期3702-3703,3739,共3页
Medical Recapitulate
