胃肠道间质瘤的临床研究进展

Progress in Clinical Research of Gastrointestinal Stromal Ttumor

胃肠道间质瘤(GIST)是一种存在频发c-kit基因突变的间叶源性肿瘤。影像学检查被广泛用于判断其生物学行为、结构特征等方面。GIST的诊断依赖于临床表现、影像学改变、病理形态学和免疫组织化学的综合应用。GIST对化学药物治疗不敏感,手术是目前最主要的治疗方法,但术后多数会复发。分子靶向治疗与外科治疗有机结合、联合应用是未来治疗GIST的发展趋势。

Gastrointestinal stromal tumor （GIST） is a kind of gastrointestinal mesenehymal tumor with frequent c-kit gene mutations. Imaging examination is frequently used in judging its biological behavior, structural feature and so on. The diagnosis of GIST depends on clinical manifestation, imaging changes, pathological morphology and immunohistochemistry. GIST is highly resistant to chemotherapy, surgery is the main therapeutic method, but there is an extraordinarily high rate of recurrence after surgical resection. The combined application of molecular targeted therapy and surgery is a developing trend in treatment of GIST.