中间高血糖与微血管并发症

Microvascular Complications and Intermediate Hyperglycemia

中间高血糖(IHG)是介于正常与糖尿病之间的血糖段,包括空腹血糖受损(IFG)与糖耐量低减(IGT)。新近发现IHG的大血管的疾病的死亡事件危险增加,其中IGT对心血管疾病的死亡危险比IFG更具有预见性,而且IFG与IGT也与类似传统的糖尿病并发症包括肾、视网膜与神经等微血管并发症独立相关,认为其机制与代谢综合征的各种因子如高血脂、胰岛素抵抗及高血糖等导致的血管内皮功能障碍有关。对中间高血糖的人群进行严格的饮食、运动的干预比药物的治疗更有效。

Intermediate hyperglycemia（IHG） is defined as concentration of blood glucose between normo- glycemia and diabetes mellitus including impaired fasting glucose（IFG） and impaired glucose tolerance （IGT）. It is found that patients with IHG had high risk of death and morbidity resulting from cardiovascular. And IGT is more better than IFG in predicting cardiovascular morbidity. [HG is also independently associated with microvascular complications that similar to traditional diabetic complications including renal disease, retinopathy, and polyneuropathy. The mechanism is considered to be related to endothelial functional disturbance resuhing from many factors in metabolic syndrome, such as hyperlipidemia, insulin resistance, and, hyperglycemia and so on.. Modifications of diet and exercise is more effective than drug treatment, for patients IHG in preventing early mierovascular complications.