摘要
观察硒和维生素A(VA)对支原体肺炎的治疗效果.方法 采用双盲随机对照2×2析因实验设计,选择100例住院支原体肺炎患儿,分为补硒组26例,补VA组23例,补硒和VA组30例以及病例对照组21例,正常组21例.一次补硒量为1mg亚硒酸钠和/或15万单位VA,对照病例组给予常规治疗.结果 与对照组比,治疗后3个补充组的症状和体征缓解天数均有不同程度缩短(P<0.05),补硒组白细胞硒和谷胱甘肽过氧化物酶水平显著上升(P<0.05),补VA、补硒组血清VA水平上升(P<0.01),细胞免疫功能有所改善.结论 硒和VA有协同作用,补充硒或同时加VA,作为辅助治疗支原体肺炎的方法,安全、有效.
To evaluate the therapeutic effects of selenium(Se) and/or vitamin A (VA) for Mycoplasma pneumonia. Methods the clinical study was conducted in 100 administered patients used a 2×2 factorial design and double blind controlled method. The patients were randomly divided into four groups, the control patients were received the routine treatment ;and the supplemented groups were given lmg sodium selenite and/ of VA 150,0001U one time only as well as the routine treatment. Results Treatment with Se and VA was superior to routine treatment in terms of improved clinical signs, needed days for relieving symptoms and signs ( P <0. 05); the levels of Se and glu-tathione peroxidase in plasma and white blood cell were increased in supplemented Se group and Se + VA group ( P <0. 05). The levels of vitamin A were increased in three supplemented groups. Higher proportion of patients in three treated groups showed normalization of T cell subset parameters as compared with the placebo group. Conclusion Synergetic interaction was present between Se and VA in certain extent, and the supplementation of Se and /or VA would be used as an additional therapeutic method for mycoplasma phenomena of children.
