摘要
为评价反映儿童锌缺乏的敏感指标.方法 我们对300名3～6岁儿童进行膳食调查与体格检查,同时测定了锌缺乏组和对照组儿童的尿锌与尿肌酐比值,血清ALP活性,血清胆固醇水平及锌缺乏儿童补锌治疗前后上述指标的变化.结果 锌缺乏组与对照组尿锌与尿肌酐比值,血清ALP活性有显著性差异.锌缺乏组儿童血浆锌,尿锌与尿肌酐比值,血清ALP活性,血清胆固醇水平在补锌治疗前后有显著性差异.结论 血浆锌和血清ALP同时降低可以预示儿童体内锌缺乏,需要补锌治疗;尿锌与尿肌酐比值能较敏感地反映儿童的锌营养状况;胆固醇与锌营养之间的关系值得进一步研究.
To estimate the sensitive indices of Zinc deficiency (ZnD) in children. Methods The urine Zn/creatinine ratio, serum ALP activity, serum cholesterol (SC) levels and changes of these parameters before and after oral zinc administration in ZnD were observed in 300 children of 3-6 years old. Results Both of urine Zn/creatinine ratio and serum ALP in ZnD differed greatly from those of control. After oral zinc administration, the plasma zinc, urine Zn/creatinine ratio and the serum ALP were greatly increased, SC level significantly decreased. Conclusions Declination of both plasma Zn and serum ALP activity can be taken as more sensitive indicators for zinc deficiency of children. Urine Zn/creatinine ratio can also sensitively reflect the zinc nutritional state. The relation between SC and zinc nutriture deserves further study.
