微创中心静脉导管留置胸腔内注药治疗恶性胸腔积液的观察

Observation of using microtrauma method with central venous catheter in the indwelling drainage and treatment for malignant pleural effusion by intrapleural injection drugs

目的探讨利用微创中心静脉导管留置胸腔内注入不同药物治疗恶性胸腔积液的疗效和安全性。方法选择由组织学和(或)细胞学诊断的恶性胸腔积液病人107例,随机分成顺铂+乌体林斯组、单用乌体林斯组、单用顺铂组3组,利用微创技术应用中心静脉导管留置胸腔给予胸腔注药。结果(1)顺铂+乌体林斯组、单用乌体林斯组、单用顺铂组有效率分别为92.5%,85.7%,53.1%;而联合组及单用乌体林斯组的疗效均明显优于单用顺铂组(P<0.05));(2)顺铂+乌体林斯组与顺铂组各种毒副反应差别无显著性(P>0.05),乌体林斯组各种毒副反应均较顺铂+乌体林斯组和顺铂组少见,其中胸痛,胃肠道反应、白细胞下降的发生率差别极有显著性(P<0.01)。结论微创中心静脉导管留置胸腔内注入乌体林斯是种治疗恶性胸腔积液安全有效,且毒副反应少的方法。

Objevtive To evaluate the efficacy and safety in the treatment of malignant pleural effusion by intrapleural injection drugs using mierotrauma method with central venous catheter.Methods 107 patients with malignant pleural effusion were randomized to three groups which were DDP plus Utilin＇s Utilin＇s or DDP.All patients were used microtrauma method with central venous catheter by jntrapleural injection drugs.Results （1）It showed that the response rates of DDP plus Utilin＇s group,tilin＇s group and DDP group were 92.5%,85.7% and 53.1% respectively.The efficacy of the DDP plus tilin＇s group or the tilin＇s group was obviously better than that of the DDP group （P〈0.05）.（2）There was no satatistical difference between the toxicitesa of the DDP plus tilin＇s group and the DDP group （P〉0.05）,the toxicities of the tilin＇s group were less than those of the DDP plus tilin＇s group or the tilin＇s group,chest pain,nausea and vomiting, leukopenia were significantly lower in the tilin＇s group（P〈0.01）.Conclusion Treating malignant pleural effusion by intrapleural administration of tilin＇ s using microtrauma method with central venous catheter is a safe,effictive and little side effects method.