环氧合酶-2与癌症治疗引起的消化道黏膜炎

Cyclooxygenase-2 and Cancer Therapy-induced Alimentary Mucositis

消化道黏膜炎是癌症治疗的主要并发症之一,可继发于放疗、化疗或两者综合治疗后。研究显示环氧合酶-2(COX-2)在消化道黏膜炎的发生、发展过程中起非常重要的作用,COX-2抑制剂则能通过抑制COX-2而减轻消化道黏膜炎,有望成为一种新的黏膜炎预防和治疗药物。本文就癌症治疗引起的消化道黏膜炎的定义和发生机制、COX-2在消化道黏膜炎中的作用以及COX-2抑制剂的疗效作一综述。

Alimentary mucositis is one of the main complications of cancer therapy. It occurs secondary to radiotherapy or chemotherapy or combination of the two. It has been reported that cyclooxygenase-2 （COX-2） may play an important role in the development and progression of alimentary mucositis, and COX-2 inhibitors can ameliorate the mucositis by inhibiting the COX-2 expression. Therefore, COX-2 inhibitors may be a novel promising drug for prevention and treatment of alimentary mucositis. This article reviewed the definition and pathogenesis of cancer therapy-induced alimentary mucositis, the role of COX-2 in alimentary mucositis, and the efficacy of COX-2 inhibitors.