摘要
目的本研究探讨常温体外循环和浅低温体外循环对小儿脑代谢的影响。方法室间隔缺损病例随机分为两组,分别在常温(35℃以上)和浅低温(32℃)下手术纠治。在ECC前、ECC结束和术后20 h检测S100蛋白浓度。用近红外线光普法(NIRS)测量脑组织氧合血红蛋白(HbO2)、脱氧血色蛋白(HbD)及氧化型细胞色素aa3(CytOx)。结果两组S100蛋白都在转流结束时明显升高,术后回落,两组比较无显著差异(P>0.05)。转流前期可见浅低温组HbO2高于常温组,升温后浅低温组HbO2显著下降,低于常温组(P<0.05)。浅低温组Cy-tOx在整个转流过程中低于常温组(P<0.05)。结论常温转流对于简单心脏病手术是安全的,不会造成神经系统明显损害。
OBJECTIVE To evaluate the effects of normothermic and mild hypothermic extracorporeal circulation （ECC） on pediatric neurological system. METHODS Patients with ventricular septum defect were randomly divided into two groups, normothermic group and mild hypothermic group. S100 protein was detected before ECC, at the termination of ECC, and post - operative 20 hours. Oxyhemoglobin（ HbO2 ）, deoxygenated hemoglobin （ HbD）, and CytOx were measured with near - infrared spectroscopy （NIRS）. RESULTS The changes of S100 protein in two groups were similar, which increased after ECC and when decreased gradually. Compared with that in the normothermic group, HbO2 was higher in hypothermic group before ECC ,while decreased quickly and was lower at the termination of ECC. During whole ECC, CytOx in hypothermic group was lower than that in normothermic group. CONCLUSION Normothermic ECC is safe for simple cardiac surgery in pediatric. It doesnt cause the severe injury of neurological system.
出处
《中国体外循环杂志》
2008年第4期201-203,共3页
Chinese Journal of Extracorporeal Circulation
关键词
体外循环
小儿
温度
神经系统
Extracorporeal circulation
Pediatric
Temperature
Neurological system
