p27表达水平与非小细胞肺癌预后关系的Meta分析

Relationship between p27 expression and prognosis of non-small cell lung cancer:a Meta-analysis study

目的:采用Meta分析的方法,探讨p27在非小细胞肺癌(NSCLC)预后中的作用。方法:检索PubMed、CNKI中研究p27表达与NSCLC预后关系的文献,收集每篇文献的相对危险比(HR)及95%可信区间(95%CI),应用Meta分析Der-simonian-Laird模型对文献进行定量综合分析。结果:共入选7篇文献,累计NSCLC病例888例,其中p27阳性表达443例,阳性率49.9%。对入选7篇文献进行一致性检验,文献具有异质性(Q=102.13,P=0.000),合并相对危险比为1.21(95%可信区间:1.13～1.29,P=0.000)。结论:p27的阳性表达可能是NSCLC的良好预后因素。

Objective：In order to determine whether p27 is a prognostic marker in non-small cell lung cancer（ NSCLC ）, we performed a systematic review of the literature to assess the prognostic value on survival of p27 in patients with NSCLC by a meta-aualysis. Methods： Articles on the relationship of p27 expression abnormality with prognosis of NSCLC were searched from PubMed database and CNKI. We abstracted the data of HR（hazard ratio） and 95% confidence interval（Cl）. The results of 7 studies were analyzed by Dersimonian-Laird method. Results：Seven studies were allowed a meta analysis of the survival, and the overall positive rate of p27 was 49. 9% among the cumulative 888 patients with NSCLC. The analysis for homogeneity（Q statistics test） showed that all eligible studies were with heterogeneity （ Q = 102. 13,P = 0. 000）. The combined HR was 1.21 （95% CI ： 1.13-1.29, P = 0. 000）. Conclusion ： p27 positive expression may be a good prognositic factor in NSCLC.