摘要
目的:观察给予丙氨酰-谷氨酰胺(Aln-Gln)双肽对腹部术后病人早期肠道通透性和应激反应的影响。方法:将20例腹部手术病人分为研究组和对照组,每组各10例。从术后第1天开始,研究组病人静脉给予Aln-Gln双肽0.5g/(kg·d),共4d;对照组病人给予同等容量的等渗盐水。于手术前、后分别检测尿乳果糖/甘露醇(L/M)比值和血浆Gln浓度、二胺氧化酶(DAO)、皮质醇和IL-6等。结果:对照组术后第5天血浆Gln浓度较术前下降16%;研究组较术前升高17%,明显高于对照组(P<0.05)。研究组术后第5天血浆DAO和尿L/M比值均较术前明显降低,并显著低于对照组,皮质醇和IL-6的恢复明显优于对照组。结论:静脉给予Aln-Gln双肽能改善腹部术后病人的肠黏膜屏障功能,减轻术后早期应激反应,有利于术后的快速康复。
Objective： The study was designed to observe the effects of alanyl-glutamine （Aln-Gln） dipeptide on postoperative intestinal permeability and stress response. Methods： A prospective, ran- domized and controlled trial was taken. 20 patients who underwent abdominal surgery were randomized into two groups： study group [ intravenous administration of Aln-Gln dipeptide, 0.5 g/（kg ~ d）, for 4 days, n = 10 and control group （normal saline as placebo, for 4 days, n = 10） ]. Serum concentrations of glutamine （ Gln）, diamine oxidase （ DAO ）, cortisol, interleukin-6 （ IL-6 ） and urine lactulose/mannito （L/M） ratio were measured before and after operation. Results： Serum Gln concentration was signifi- cantly decreased in control group and increased in study group on postoperative day 5. Urine L/M ratio was significantly increased in control group and decreased in study group. The serum concentrations of DAO, cortisol and IL-6 were significantly decreased in study group while compared with control group. Conclusion ： Administration of Aln-Gln dipeptide can increase the level of serum Gln, decrease the intestinal permeability and attenuate the stress response in the early period of postoperative patients. Aln-Gln dipeptide can be used in the fast track surgery.
出处
《肠外与肠内营养》
CAS
2008年第6期343-346,共4页
Parenteral & Enteral Nutrition
基金
江苏省社会发展基金资助项目(BS2007054)
