早期高蛋白代谢支持加生长激素对重度颅脑损伤病人的影响

The effect of early higher protein nutrition support and growth hormone in patients with severe craniocerebral injury

目的：探讨早期高蛋白质代谢支持加生长激素对重度颅脑损伤病人的影响。方法：将60例重度颅脑损伤病人随机分为观察组和对照组，每组30例。观察组在入院24h后按2～2．5g／（kg·d）给予蛋白质，同时加用生长激素；对照组给予蛋白质1．2～1．5g／（kg·d），均连用1周，测定两组病人入院第1、4和7天时有关营养指标的变化，并观察两组病人的临床疗效和并发症。结果：观察组病人的血清PA、ALB、TF和Hb均明显高于对照组。观察组平均入住ICU的时间明显短于对照组，预后明显优于对照组。两组病人肝肾功能、内环境和病死率等差异无显著性意义。结论：早期使用高蛋白质代谢支持加生长激素，能明显减轻重度颅脑损伤病人的蛋白质丢失，缩短入住ICU的时间，并改善病人的预后。

Objective： To explore the effects of early higher protein nutrition support and growth hormone in patients with severe craniocerebral injury. Methods： 60 patients with severe craniocerebral injury were randomized into observation group and control group. The observation group （30 eases） had re- ceived on higher protein nutrition support [2～2.5 g/（ kg · d）] and growth hormone for one week. The control group（30 cases） had received lower [ 1.2～1.5g/（kg·d）） protein nutrition support] for one week. The levels of protein index were determined. The clinical effect and complication were compared between the two groups. Results： The serum prealbumin, albumin, transferrin and hemoglobin in the observation group were significantly higher than those in the control group. The staying time in ICU was significantly shorter and the progrosis was better in the observation group. There were no statistical differ- ences about the index of liver function, renal function and the morbility between the two zrouns. Conclusion： Early higher protein nutrition support and growth hormone can improve the nutrition status and the prognosis of patients with severe eraniocerebral injury.