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稳定性心绞痛患者内皮祖细胞与侧支循环之间的关系探讨 被引量：1

Relationship between circulating endothelial progenitor cells and coronary collateral circulation in patients with stable angina pectoris
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摘要 目的:探讨稳定性心绞痛(SAP)冠状动脉有重度狭窄或完全闭塞患者循环内皮祖细胞(EPCs)与侧支循环的关系。方法:将2006年3月至2007年8月期间入院的稳定性心绞痛患者,经冠状动脉造影检查冠脉有重度狭窄或完全闭塞的,将其侧支循环根据Rentrop分级分为0、1、2、3级,Rentrop分级≥2级者归为侧支循环良好组(Coll+组,n=15),≤1级者归为侧支循环不良组(Coll-组,n=15),共2组。经造影导管抽取血样标本,分离培养单个核细胞。激光共聚焦显微镜鉴定Dil标记的乙酰化低密度脂蛋白(Dil-acLDL)和FITC标记的荆豆凝集素-1(FITC-UEA-1)双染色阳性细胞为正在分化的EPCs,并计数。采用改良的Boyden小室和MTT法分别测定其迁移能力及增殖能力。结果:Coll+组内皮祖细胞数量(60.9±9.6)EPCs/视野(×400)显著高于Coll-组(31.0±4.1)EPCs/视野,P(0.01,其迁移能力和增殖能力也明显强于Coll-组(P<0.01),相关性分析显示EPCs的数量、迁移能力和增殖能力与侧支循环程度呈正相关。结论:本研究显示了稳定性心绞痛患者循环内皮祖细胞与侧支循环的形成之间存在着关联性。
作者 陈继舜 杨汉东 闵新文 李东峰 陈欣 何培根 许浩
机构地区 武汉大学人民医院心内科 郧阳医学院附属东风医院心内科
出处 《中国病理生理杂志》 CAS CSCD 北大核心 2008年第12期2475-2477,共3页 Chinese Journal of Pathophysiology
关键词 内皮祖细胞 侧支循环 冠状动脉疾病 Endothelial progenitor cells Collateral circulation Coronary disease
分类号 R363 [医药卫生—病理学]
  • 相关文献

参考文献10

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共引文献27

同被引文献14

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中国病理生理杂志
2008年 第12期

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