SORL1基因多态与阿尔茨海默病发病风险的Meta分析

Meta-analysis of the relation between the SORL1 gene polymorphism and the onset risk of Alzbehner＇s disease

目的运用Meta分析的方法探讨SORL1基因rs2070045位点基因多态与阿尔茨海默病（AD）发病风险的关系。方法应用SORL1、sortilin—related receptor、Alzheimer等关键词，检索Medline、Cochrane图书馆和中国生物医学文献数据库（CBM）发表的文章并附以文献追溯方法。应用RevMan4．2软件进行统计分析。结果三篇文献共11组不同种族人群纳人分析．共有AD组2927例，对照组3869例。AD组和对照组rs2070045位点基因多态现象中GG＋GT基因型频率与最常见的纯合子TT基因型频率比的合并比值比（OR）值为1．19，95％可信区间为1．08～1.31．Z=3.39．P=-0．0007，等位基因频率合并OR值为1．17，95％可信区间为1．07～1．27，Z=3．67，P=0.0002。结论SORL1基因rs2070045位点多态性与AD患病风险相关。

Objective To investigate the relation between the rs2070045 locus polymorphism in the SORL1 gene and the onset risk of AD by means of Meta-analysis. Methods Databases （Medline, Cochrane Library and CBM） were searched using keywords like SORL1, sortilin-related receptor, Alzheimer and so on, and a manual search of citations was also performed from relevant original studies and literatures. All analyses were conducted with Review Manager Version4.2 software. Results 3 literatures with 11 different ethnic groups were studied, totally including the AD group （2927 cases） and the control （3867 cases）. The summary OR for studies with frequency ofGG＋GT genotype at rs2070045 locus in the SORL1 gene was 1.19 （95%CI： 1.08-1.31, Z=3.39, P=0.0007）, when it compared with the common homozygote of TT genotype. The summary OR for allele frequency was 1.17 （95%CI： 1.07-1.27, Z=3.67, P=0.0002）. Conclusion The meta-analysis suggests that the polymorphism at rs2070045 locus ofSORL1 gene might be a genetic risky factor for AD.