骨刺灵Ⅱ号对骨质增生性疼痛及TXB_2、6-K-PGFla调节的临床研究

Clinical Study of GucilingⅡ on Pain of Hyperosteogeny and Serum TXB_2 and 6-K-PGFla

目的:揭示骨刺灵Ⅱ号治疗骨质增生的作用机理。方法:将60例患者分为骨刺灵组和坎离砂组,于治疗前后测定患者血浆中TXB2和6-K-PGFla的变化,并对比总疗效及单项症候疗效。结果:两组患者治疗前血浆中的TXB2和6-K-PGFla比较差异无统计学意义,治疗后骨刺灵组TXB2明显降低、6-K-PGFla明显升高;骨刺灵组治疗前后的TXB2、6-K-PGFla比较,差异有统计学意义,P<0.01;总疗效、单项疗效骨刺灵组优于坎离砂组,两组各单项的症候治疗前后比较差异均有统计学意义,P<0.001。结论:骨刺灵治疗骨质增生性疾病有很好的疗效。

Objective：To investigate the mechanism of Guciling Ⅱ in the treatment of hyperosteogeny. Methods： Sixty pa- tients were randomly divided into Guciling group and Kanlisa group. Serum TXB2 and 6--K--PGFla were measured before and after treatment. Also, total effective rate and single symptomatic effectiveness were observed. Results：Before the treatment, there was no difference in serum levels of TXB2 and 6-K-PGFla between the two groups. After the treatment, TXB2 in Guciling group was obviously increased and 6-- K-- PGFla significantly decreased. There was statistical difference of TXB2 and 6-K-PGFla in Guciling group between before and after treatment. Total effective rate and single symptomatic effective rate in Guciling group were markedly higher than those in the Kanlisa group. Conclusion： Guciling is effective for hyperosteogeny. By improving content of 6-K-PGFla and decreasing content of TXB2, the effect of activating blood and dissolving stasis was obtained, thus capillary permeability was decreased, edema was controlled and blood stasis was reduced.