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间充质干细胞在胶原诱导性关节炎中的研究进展

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摘要 类风湿关节炎（rheumatoid arthritis，RA）是一种以慢性、进行性多关节炎为主要表现的疾病。其病理特征表现为持续进行性滑膜炎，软骨破坏和骨侵蚀，最终导致关节强直、畸形、功能丧失。胶原诱导性关节炎（collagen-indueed arthritis，CIA）是研究RA的动物模型，用于对RA的病因、发病机制、药物筛选和治疗等研究。CIA在病理上与RA很相似，表现为滑膜增生、炎症细胞浸润、血管翳形成、软骨破坏和骨侵蚀等。
作者 周涛 孙凌云
机构地区 南京大学医学院附属鼓楼医院风湿免疫科
出处 《中华风湿病学杂志》 CAS CSCD 2008年第12期844-846,共3页 Chinese Journal of Rheumatology
基金 基金项目：江苏兴卫工程人才基金（RC2007002）
关键词 胶原诱导性关节炎 间充质干细胞 类风湿关节炎 炎症细胞浸润 病理特征 软骨破坏 主要表现 多关节炎
分类号 R686 [医药卫生—骨科学]
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参考文献32

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二级参考文献19

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中华风湿病学杂志
2008年 第12期

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