加用含镁极化液治疗脑卒中后癫痫的临床观察

Clinical research on the treatment of epilepsy after stroke with magnesium polarized liquid

目的观察加用含镁极化液治疗脑卒中后癫痫的疗效和对神经元保护的作用。方法120例脑卒中后癫痫患者随机分为治疗组和对照组(各60例)。对照组按脑卒中治疗原则及抗痫治疗,治疗组在常规治疗的基础上加用含镁极化液。结果治疗组癫痫临床治愈、有效和无效的例数分别为34、24、2,对照组为32、23、5,治疗组优于对照组(Hc=4.463,P<0.05)。治疗组神经功能缺损痊愈、显著进步、进步、无变化和恶化的例数分别为8、35、8、3、6;对照组为3、24、12、13、8,治疗组优于对照组(Hc=8.759,P<0.01)。治疗后治疗组总智商评分较治疗前低,差异有统计学意义(P<0.05);治疗后对照组总智商、数字广度、词汇、言语智商评分低于治疗前,差异有统计学意义(P<0.05)。治疗后治疗组总智商、数字广度、词汇、言语智商评分高于对照组,差异有统计学意义(P<0.01或0.05)。结论在常规治疗基础上加用含镁离子极化液可提高脑卒中后癫痫患者的癫痫控制率,同时具有神经元保护作用,减少神经功能缺损,能提高患者的认知功能。

Objective To research on the treatment of epilepsy after stroke with magnesium polarized liquid （GIKMg）. Methods 120 cases of epilepsy after stroke were divided into treatment group and control group, each with 60 cases. The control group was teated with anti-epilepsy according to the therapeutic principle of stroke. The treatment group was treated with GIKMg on the basis of conventional therapy. Results The clinical cure rate of epilepsy was 56.7 % in the treatment group and 38.3 % in the control group, with statistical significance （ P 〈 0.05） ; The total improving rate of neurologic impairment was 85 % in the treatment group and 66.7 % in the control group, with statistical significance （ P 〈 0.05 ） ; The neuropsychology test scores were higher in the treatment group than those in the control group, with statistical significance （P 〈 0.05）. Conclusion GIKMg therapy could increase the cure rate of epilepsy after stroke, protect the neurons, decrease the neurologie impairment, and improve the cognitive function of patients.