Fbx4蛋白质及其研究进展

Research on Fbx4 protein

泛素介导的蛋白降解途径参与了许多生物学过程。SCF复合体是一种非常重要的E3泛素连接酶，F-box蛋白是SCF复合体的一个亚基，Fhx4蛋白是众多F-box蛋白中的一种，是底物特异性识别SCF^Fbx4/αB-crystallin酶的重要组成部分，Fbx4蛋白失活或表达水平改变影响SCF^Fbx4/αB-crystallin酶活性，从而影响细胞周期蛋白D1的表达水平。同时Fbx4蛋白还是端粒长度调节的一个重要调控因子。

Protein degradation mediated by ubiquitin-proteasome pathway is involved in many biological processes. SCF complex is a sort of important E3 ubiquitin-ligase enzyme. Fbx4 protein is one of F-box protein family members, an important component of substrate-specific SCF^Fbx4/αB-crystallin ligase, and a subunit of SCF complex. Inactivation of Fbx4 protein or alteration of its expression level will influence activity of SCFF^Fbx4/αB-crystallin ligase, thus will influence expression level of Cyclin D1. And Fbx4 protein is also an important regulatory factor for telomere maintenance.