散发性甲状旁腺腺瘤基因改变的研究进展

Progress of gene in sporadic parathyroid adenomas

散发性甲状旁腺腺瘤是引起原发性甲状旁腺功能亢进的重要原因。但甲状旁腺腺瘤发病机制不清且缺乏早期特异性诊断指标。近年来随着分子生物学的发展，甲状旁腺腺瘤在基因水平的研究取得了很大的进展。本文就其在分子生物学的改变做一综述。

Sporadic parathyroid adenomas are the most common cause of primary hyperparathyroidism. The molecular mechanisms underlying the pathogenesis of sporadic parathyroid adenomas are incompletely understood and early specifical diagnosis is lack. With the development of molecular biological technology, gene research in parathyroid adenoma has made great progress. This article reviewed the changes at the molecular level.