溃疡性结肠炎患者对C反应蛋白水平变化的临床疗效研究

Clinical Effect on Ulcerative Colitis Patients to C-reaction Protein Level Change

目的探讨血C-反应蛋白(CRP)水平在溃病性结肠炎(UC)患者病情活动性与严重程度评价中的意义。方法对UC患者86例以及健康对照42例,采集外周血,检测血清CRP、血沉及其他生化指标(肝功能、肾功能、免疫球蛋白)水平,重点分析CRP在不同临床时期的变化,并评估其与其他临床指标之间的相关性。结果活动性UC患者血清CRP浓度明显高于健康人(P<0.01)。重度UC患者血清CRP水平显著高于中度UC患者(P<0.05);中度UC患者血清CRP水平也显著高于轻度UC患者(P<0.05)。活动性UC患者经过有效药物治疗后,血清CRP水平呈明显下降(P<0.05)。相关分析发现活动性UC患者的临床严重程度与血清CRP水平之间呈正相关关系(r=0.91,P<0.01),而其他实验室指标(如ESR、肝功能、肾功能、免疫球蛋白)之间无明显相关性(P>0.05)。结论CRP水平变化可以准确地反映UC患者临床严重程度,为临床上治疗,控制病情发展,以及判断预后提供了重要的理论依据。

Objective： To investigate the Abstract of blood C-reactive protein （CRP） levels in ulcer disease colitis （UC） in patients with disease activity and severity of the evaluation. Methods ：86 cases of patients with UC, as well as 42 cases of healthy controls, the collection of peripheral blood, serum CRP, ESR and other biochemical markers （liver function, kidney function, immune globulin） level of CRP analysis focused on different clinical period of change and To assess the clinical and other indicators related to each other. Results： the activities of UC in patients with serum concentrations of CRP were significantly higher than healthy people （P 〈0.01 ） . UC patients with severe levels of CRP were significantly higher than moderate UC patients （P 〈0.05） ; moderate UC in patients with serum CRP levels were significantly higher than UC patients with mild （P 〈0.05） . Active UC in patients after effective treatment, serum CRP levels were significantly decreased （P 〈0.05） . Analysis found that the activities of UC patients and the severity of serum CRP levels between the positive correlation between （r = 0.91, P 〈0.01 ） , while the other laboratory indicators （such as ESR, liver function, kidney function, immune globulin） , There was no significant correlation （P〉 0.05 ） . Conclusion： CRP levels can be accurately reflect the severity of clinical patients with UC, for the clinical treatment and control of disease development, prognosis, as well as provide important theoretical basis.