造血系统的人类疱疹病毒潜伏感染

Latent Infection of Human Herpes Virus in Hematopoietic System

随着造血干细胞移植和器官移植的广泛开展,人类疱疹病毒潜伏感染引起的移植失败和并发症的报道日益增多,受到了广泛的关注。细胞因子风暴最早是作为移植物抗宿主病的发病机制提出的,近年来在炎症的发病学研究中也广为运用,在严重的病毒感染中起重要作用。本文就人类疱疹病毒潜伏感染导致骨髓或干细胞移植失败或引起并发症,以及在难治性白血病中的可能作用进行了讨论,以探讨人类疱疹病毒潜伏感染及其引起的细胞因子风暴的作用和意义。

Up to date, eight types of human herpes viruses have been identified, all of which are ubiquitous, and usually establish latent infection in the host after primary infection. Since most of the herpes viruses are maintained in an asymptomatic form, they are often neglected. However, under some circumstances, these herpes viruses can cause fatal or severe diseases. Furthermore, the association of herpes viruses with hematopoietic malignancies is attracting researchers＂ attention. With the extensive development of bematopoietic stem cell and organ transplantation, reports regarding transplantation failure and complication caused by infection of human herpes virus has been increasing. Cytokine storm was firstly suggested as the mechanism of graft-versus-host diseases. In recent years, which has also been applied in the pathogenesis research of inflammation, and is supposed to play an important role in severe virus infection. In this paper, through discussing the possible role of latent infection of human herpes virus in the failure or complication of bone marrow or hematopoietic stem cell transplantation, and in refractory leukemia, the function and significance of latent infection of human herpes virus and the cytokine storm it caused were investigated.