NK细胞活性在诊断继发性噬血细胞综合征中的意义探讨

Diagnostic Significance of NK Cell Activity in the Patients with Hemophagocytic Syndrome

本研究探讨继发性噬血细胞综合征(hemophagocytic syndrome,HPS)患者外周血NK细胞活性水平及其在早期诊断中的意义。采用LDH释放法检测16例凝似HPS患者和25名正常健康人外周血NK细胞的活性,并将确诊继发性HPS患者的NK细胞活性与正常人NK细胞活性进行比较。结果表明:16例疑似HPS患者中有8例最终确诊为继发性HPS,其NK细胞活性均明显低于正常对照组,两者相比差异有显著统计学意义(p<0.001),且已确诊患者的NK细胞活性在疾病早期即出现异常。结论:NK细胞活性的检测对于HPS的早期诊断可能具有重要意义。

This study was aimed to explore the level of NK cell activity in the patients with secondary hemophagocytic syndrome （HPS） and its significance for early diagnosis of this disease. 16 suspected HPS patients and 25 healthy subjects were enrolled in this study. The activity of NK cells in peripheral blood was detected by a released LDH assay. The activity level of NK cells in peripheral blood from patients who were finally diagnosed as HPS was compared with healthy subjects. The results showed that 8 out of 16 suspected HPS patients were finally diagnosed as secondary HPS. The activity of NK cells in peripheral blood of these 8 patients was obviously lower than that in healthy subjects with statistical significance （p 〈 0.001 ）, and showed abmormal in the early stage of this disease. It is concluded that the detection of NK cell activity may play an important role in earlier diagnosis of secondary hemophagocytic syndrome.