结核性脑膜炎患者脑脊液S100B、IL-1β动态演变及临床意义

The Dynamical Progeression and Clinical Significance of S100B and IL-1βof Cerebrospinal Fluid in Patients with Tuberculous Meningitis

目的探讨结核性脑膜炎患者脑脊液S100B、白细胞介素-1β(IL-1β)动态变化及二者的相关性。方法43例结核性脑膜炎患者(TBM组)分为昏迷组和无昏迷组,均给予标准抗结核治疗。选择无神经系统疾病的腰麻术患者28例作为对照组。TBM组和对照组均于发病后1～6天首次采集脑脊液,以后每隔5～7天采集1次,共5次。采用酶联免疫吸附试验(ELISA)、放射免疫法测定3组患者不同病程脑膜炎S100B、IL-1β含量。结果15例发生昏迷(昏迷组),28例未发生昏迷(无昏迷组)。昏迷组和无昏迷组S100B、IL-1β含量较对照组均显著增高(P<0.05);昏迷组较无昏迷组患者脑脊液S100B、IL-1β含量增高明显。随时间的延长,S100B维持于较高水平,而IL-1β的含量不断下降。结论结核性脑膜炎患者脑脊液S100B含量的高低能够反映病情的严重程度,IL-1β对治疗反应更灵敏。

Objective To explore the dynamical progeression and clinical significance of SIOOB and IL - 1 β of cerebrospinal fluid in patients with tuberculous meningitis. Methods 43 patients with TM（TM group） treated with tubercle drug and 28 patients without never diseases （ control group） have been studied. S100B in Cerebrospinal Fluid were exeminated by ELISA and IL - 1β by radio - immunassay. Results SIOOB or IL - 1β of cerebrospinal fluid in patients with tuberculous meningitis increased evidently in contrast with the control group. And S100B or IL - 1β of Cerebrospinal Fluid in coma patients increased evidently in contrast with no coma. Conclusion The levels of S100B in CSF could reflex the degree of damage in patients with TM. IL - 1β was more sensitive to treatment.