血清胆红素水平与女性冠心病关系的探讨

Relationship between serum bilirubin level and coronary heart disease in female

目的:探讨血清胆红素水平与女性冠心病的关系。方法:109例女性患者按冠状动脉造影结果分为冠心病组(74例)和非冠心病组(35例)。同时测定血清胆红素及各项生化指标。冠状动脉狭窄程度用冠状动脉狭窄计分表示。结果:女性冠心病组血清总胆红素、直接胆红素和间接胆红素水平均显著低于非冠心病组(P<0.01)。相关分析显示,女性冠心病组直接胆红素与总胆固醇(TC)和甘油三酯(TG)呈显著负相关(r1=-0.398,r2=-0.405,P均<0.01)。三种胆红素水平与冠状动脉病变积分均不呈负相关。结论:低血清胆红素水平是冠状动脉粥样硬化的危险因素。

Objective： To study the relationship between serum bilirubin level and coronary artery disease in female. Methods： A total of 109 female patients underwent coronary angiography were observed. The patients were divided into coronary artery normal group （35 cases） and coronary artery disease group （74 cases） according to the result of coronary angiography. At the same time, the serum bilirubin and biochemical indexes of patient were measured by routine assay. The degree of coronary artery disease was denoted with the score of coronary artery stenosis. Results： The serum bilirubin in coronary artery disease group were significantly lower than that in control group （P〈0.01）. Line correlation analysis between direct bilirubin and serum lipid showed that direct bilirubin and total cholesterol, triglyceride had remarkable inverse correlation and the serum bilirubin was not negatively correlated with the score of coronary artery stenosis. Conclusion.. The low serum bilirubin content is an independent risk factor of coronary artery disease.