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厄贝沙坦对慢性心力衰竭患者的疗效观察 被引量:14

Therapeutic effect of irbesartan on patients with chronic heart failure
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摘要 目的:观察厄贝沙坦对慢性心力衰竭(CHF)患者的治疗效果及安全性。方法:2004年6月~2007年6月我院心内科共收治CHF患者193例,入院后病人均以血管紧张素转换酶抑制剂(ACEI)、β受体阻滞剂、洋地黄类、利尿剂作常规抗心力衰竭治疗,对达到全剂量常规抗心力衰竭治疗的71例CHF患者,在剔除收缩压〈100mmHg、风心病及肥厚性心肌病病人后进行随机对照试验,厄贝沙坦治疗组(36例)在常规抗心力衰竭药物基础上加用厄贝沙坦,对照组(35例)原治疗不变,两组疗程均为12周。观察治疗前、后两组病人心功能、肾功能、超声心动图左室射血分数(LVEF)值,左室短轴缩短率和6min步行试验(6~MWT)的变化。结果:治疗12周后。两组心功能分级,6-MWT,超声心动图检查的LVEF与治疗前比较有明显改善(P〈0.05~〈0.01),且治疗组的显著优于对照组(P〈0.05~〈0.01)。结论:常规治疗联用厄贝沙坦对慢性心力衰竭患者,可进一步获得有益的疗效,并且有良好的安全性和耐受性。 Objective.. To study the therapeutic effect of irbesartan on patients with chronic heart failure (CHF). Methods: The 71 CHF patients accepted anti-CHF therapy of whole dose (exclude patients with SBP〈100 mmHg, rheumatic heart disease and hypertrophic cardiomyopathy) were divided into therapy group (treated with irbesartan based routine anti-CHF therapy, 36 cases) and control group (treated with routine anti-CHF therapy, 35 cases), therapeutic course was 12 weeks all. Results.. After therapy of weeks, the NYHA heart function, 6-minute walk test (6-MWT), LVEF and fractional shortening of left ventricular brachyaxis of two groups significantly improved (P〈0.05-〈0.01), but those of therapy group more improved (P〈0.05-0.01) compared 'with control group. Conclusion: Irbesartan combine routine anti-CHF therapy may further and safely improve therapeutic effect of CHF patients.
出处 《心血管康复医学杂志》 CAS 2008年第6期562-564,共3页 Chinese Journal of Cardiovascular Rehabilitation Medicine
关键词 心力衰竭 充血性 厄贝沙坦 治疗结果 Heart failure, congestive Irbesartan Therapeutic effect
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