摘要
目的研究异黄酮改构化合物F11对人乳腺癌裸鼠移植瘤影响。方法体外培养人乳腺癌MCF-7细胞,裸鼠皮下接种MCF-7细胞建立裸鼠移植瘤动物模型,用金雀异黄素(Genistein)和环磷酰胺为对照研究化合物F11在体抗MCF-7效应。结果通过裸鼠移植瘤模型检测,认为异黄酮改构化合物F11在体有显著的抗癌效应,效果优于Genistein。结论异黄酮改构化合物F11有较强的抑制肿瘤的作用,有值得进一步研究开发的潜在价值。
Aim To investigate the effect of isoflavone derivave F11 on transplant breast cancer in nude mice.Methods Models were constructed through hypodermic inoculation of MCF-7 in nude mice. The anti-tumor activity of F11 was studied by comparing it to Genistein and Cytoxan. Results F11 had better performance than Genistein in anti-tumor tests on transplant tumor models in nude mice. Conclusion Isoflavone derivative F11 has better effect on tumor ceils and is of potential clinical value and worthy of further investigation.
出处
《解放军药学学报》
CAS
2008年第6期507-510,共4页
Pharmaceutical Journal of Chinese People's Liberation Army
基金
重庆市院士基金资助项目
No.2004BC5006
