摘要
目的探讨直肠癌淋巴结转移与临床病理特征及术后生存时间之间的关系。方法分析67例行全直肠系膜切除术患者的性别、年龄、肿瘤原发灶大小、大体类型、浸润深度、组织学类型、分化程度及术前血清癌胚抗原(CEA)水平与术后淋巴结病检转移情况及与生存时间的关系。结果单因素分析结果发现,肿瘤大小、大体类型、浸润深度、组织学类型、分化程度与淋巴结转移相关;进一步多因素分析结果提示,组织学类型、分化程度与淋巴结转移相关。全组5年生存率为59.7%;无淋巴结转移组预后好于有淋巴结转移组,两生存曲线比较差异有统计学意义(χ2=13.658,P=0.000)。结论直肠癌组织学类型和分化程度是淋巴结转移的主要危险因素,根据患者临床病理特征和淋巴结转移之间的相关性能够更准确诊断病情、制定治疗方案以及判断预后。
Objective To investigate the correlation between lymph node metastasis and clinical factors, prognosis in rectal cancer. Methods Collected the statistics of 79 cases who accepted total mesorectal excision（ TEM）, such as clinical factors, prognosis and lymph node metastasis. And analyzed the correlation between the third and the preceding two factors. Results There was significant correlation between five factors （ namely the tumor size, massive type, depth of invasion, histology type and differentiating degree ） and lymph node metastasis in monovariate analysis. However only two factors-histology type and differentiating degree-were left in multivariate analysis. The 5-year survival rate of total group was 59.7%. The prognosis of nolymph metastasis group was statistically better than that of the group with metastasis （χ^2 = 13. 658, P = 0. 000）. Conclusion Histology type and differentiating degree are main risk factors of lymph node metastasis in rectal cancer. Doc- tor can more accurately diagnose, make therapeutic regimen and judge prognosis of patients with rectal cancer according to the correlation between lymph node metastasis and elinicopathologic factors.
出处
《中国实用医药》
2008年第34期48-50,共3页
China Practical Medicine
