冠心病心力衰竭患者应用曲美他嗪的临床对照研究

The clinical therapeutic study of trimetazidine for the coronary heart disease and heart failure

目的探讨冠心病心力衰竭患者的治疗方法,以积累经验,指导临床诊疗。方法收集本院诊治的95例冠心病心力衰竭患者,随机分为观察组和对照组,对照组(43例)应用利尿剂、血管紧张素转换酶抑制剂、β受体阻滞剂及洋地黄类制剂进行常规治疗,观察组(52例)在常规治疗基础上加用曲美他嗪。结果观察组的疗效明显优于对照组,左室射血分数改善明显,不良反应少。结论曲美他嗪对冠心病心力衰竭患者疗效好,不良反应少,临床中适合推广应用。

Objective To investigate the treatment methods of coronary heart disease and heart failure, for accumulating clinical experience and directing the clinical work. Methods 95 patients were divided into two groups. The control group（43 cases） were treated by routine treatment,and the observation group（52 ca- ses） were treated by routine and trimetazidine treatment. Results The total effective rates were higher in the observation group than the control group. The LVEF were improved significantly in the observation group. The frequency of adverse reaction was lower in observation group. Conclusions The treatment of trimetazidine is worthy of being recommended in patients with coronary heart disease and heart failure.