金芪降糖片对2型糖尿病尿微量白蛋白排泄率的影响

The effect of Jinqi hypoglycemic tablet on urine albumer excretion rate in patients with type 2 diabetes

目的探讨金芪降糖片对2型糖尿病患者尿微量白蛋白排泄率(UAER)的影响。方法选择2型糖尿病经单纯饮食治疗血糖控制失败并伴早期糖尿病肾病29例随机给以金芪降糖片或二甲双胍治疗6个月,比较两组间UAER的差别。结果治疗前两组间UAER无明显差别(65.9±16.1)vs(63.6±18.6)μg/min,P=0.2693。治疗六个月时金芪降糖片组UAER(43.7±11.5)μg/min较二甲双胍组(56.6±12.0)μg/min明显降低(P=0.0065)。结论金芪降糖片除降血糖作用外还具有潜在的降尿微量白蛋白作用,有价值进一步探讨。

Objective To investigate the effect of Jinqi hypoglycemic tablet on urine albumer excretion rate （UAER）in patients with type 2 diabetes. Methods Twenty nine patients with type 2 diabetes in plasma glucose poorly controlled with diet treatment accompanied by early diabetic nephropathy were randomly treated with Jinqi hypoglycemic tablet and mefformin for 6 months, and were evaluated by differences of UAER between Jinqi hypoglycemic tablet and metformin group. Results There was no significant difference in UAER between the two groups before treatment（65.9 ± 16.1vs63.6 ± 18.6 μg/min,P = 0. 2693 ）. By 6 months of treatment, UAER in Jinqi hypoglycemic tablet group （43.7 ±11.5 μg/min ） was significantly lower（ P = 0. 0065 ） than etformin group（56. 6 ± 12. 0μg/min）. Conclusion There is a potential effect of reducing UAER in Jiqi hypoglycemic tablet excluded glucose lowering effect so it is valuable to further study on.