血清和胸液中肿瘤标志物联合检测对肺癌引起的胸腔积液临床意义分析及比较

Analysis and comparison of the significance of measuring tumor maker in pleural effusions caused by lung cancer

目的探讨胸腔积液患者血清和胸水中癌胚抗原(CEA)、CYFRA21-1、神经元特异性烯醇化酶(NSE)的含量变化、对肺癌引起的胸腔积液诊断的临床意义及比较。方法肺癌组和对照组患者共62例,分别测量其血清和胸水中的CEA、CYFRA21-1、NSE的含量,并进行比较。结果肺癌组患者血清和胸水肿瘤标志物均明显高于对照组(P<0.05)。在肺癌组中,胸水CEA、CYFRA21-1均明显高于血清组(均P<0.005),而胸水和血清NSE比较差异无统计学意义(P>0.05)。对照组中胸水和血清各项指标比较差异无统计学无意义(P>0.05)。结论肺癌引起的胸腔积液肿瘤标志物检测胸水的阳性率要高于血清;而临床上联合检测肿瘤标志物对于肺癌诊断的意义更大。

Objective To explore the change of quantities and clinic significance of CEA, CYFRA21- 1, NSE in serum and pleural effusions of patients with malignant pleural effusions caused by lung cancer. Methods 62 cases were divided into two groups ; lung cancer group and pneumonia group; investigator measured and compared quantities of CEA, CYFRA21-1, NSE in serum and pleural effusions. Results In lung cancer group tumor markers in serum and pleural effusions were obviously higher than pneumonia group （ P 〈 O. 05 ）. In lung cancer group, quantities of CEA and CYFRA21-1 in pleural effusions were obviously higher than those in serum （P 〈 0. 005 ） , it was no significance for quantities of NSE in pleural and serum effusions （P 〉 0. 05 ）. In pneumonia group, it was no significance for quantities of CEA ,CYFRA21-1, NSE in pleural and serum effusions （P 〉 0. 05 ）. Conclusion In malignant pleural effusions caused by lung cancer, the positive rate of tumor markers in pleural effusions was higher than that in serum; for the clinic work, there was great significance in diagnosis of lung cancer by measuring tumor markers in combining pleural effusions and serum.