BEP方案治疗恶性滋养细胞肿瘤42例临床分析

The short-term curative effect of chemotherapy with BEP regimen in malignant gestational trophoblastic tumour

目的研究BEP方案治疗妊娠恶性滋养细胞肿瘤的疗效及化疗不良反应。方法1998年2月至2006年3月,采用BEP方案治疗妊娠恶性滋养细胞肿瘤42例,其中初治患者28例,耐药患者11例,复发患者3例。结果该方案治疗42例妊娠恶性滋养细胞肿瘤患者,37例完全缓解,总完全缓解率为89.09%。其中初治侵蚀性葡萄胎的治愈率为100%,耐药绒癌的完全缓解率为91.44%,复发性妊娠恶性滋养细胞肿瘤的完全缓解率为100%。化疗不良反应主要为I-Ⅱ级恶心、呕吐和骨髓抑制。结论采用BEP方案治疗妊娠恶性滋养细胞肿瘤疗效可靠,对其他药物耐药或复发病例也可获得满意的疗效,化疗不良反应轻,患者易接受,值得进一步研究。

Objective To evaluate the response rate and toxicity of Bleomycin, Etoposide, k and Cisplatin （BEP） regimen for women with malignant gestational trophoblastic tumour. Methods Forty-two patients with malignant gestational trophoblastie tumour were treated by BEP regimen. Results Forty-two patients received the study regimen and 37 cases （ 89.09% ） achieved a complete remission The main complications for BEP chemotherapy were myelosuppression and gastrointestinal symptoms. Conclusion The BEP regimen is an effective treatment for malignant gestational trophoblastic tumour.