摘要
目的观察纳洛酮治疗AECOPD并发Ⅱ型呼吸衰竭的临床疗效。方法将65例病例随机分为治疗组及对照组,两组均予以积极控制感染,持续低流量吸氧,解痉平喘,止咳化痰,营养支持等综合治疗。治疗组在此基础上加用纳洛酮注射剂,首剂负荷量0.8mg加入生理盐水20ml中静脉推注,以后给予纳洛酮注射剂2mg加入生理盐水100ml中,缓慢持续静脉滴入,12h/次,24h纳洛酮总剂量为4mg,连用3d。结果治疗组总有效率显著高于对照组(P<0.05);动脉血气分析指标:动脉血氧分压(PaO2)显著高于对照组(P<0.05)、动脉血二氧化碳分压(PaCO2)显著低于对照组(P<0.05);结论纳洛酮治疗AECOPD合并呼吸衰竭临床疗效确切。
Objective To observe the clinical effect of naloxone in treatment of AECOPD with type Ⅱ respiratory failure. Methods The 65 patients of AECOPD with type Ⅱ respiratory failure were randomly divided into target group 33 and control group 32. Both were treated with regular drug therapy. The target group was given naloxone injection 2 mg intravenous drip for 3 days. Results After treatment, the overall effective rate in the target group was significantly higher than that in the control group （ P 〈 0. 05 ）. Conclusion Naloxone is effective for treatment of AECOPD with type Ⅱ respiratory failure.
出处
《中国实用医药》
2008年第36期69-70,共2页
China Practical Medicine
