213例对阿莫西林和克拉霉素耐药的幽门螺杆菌感染者的治疗分析

The analyse of the effect to 213 patients infected by helicobacter palori Amoxicillin and Clarithromycin

目的对阿莫西林和克拉霉素耐药的幽门螺杆菌(Hp)感染者的治疗方案的疗效分析,并进行比较,寻找较为行之有效的治疗方案。方法回顾性分析213例幽门螺杆菌感染者的不同治疗方案的治疗结果。入选患者分别接受质子泵抑制剂(咯赛克20mg,1次/d)+左氧氟沙星胶囊(0.2,3次/d)+呋喃唑酮(0.1,3次/d)和质子泵抑制剂(咯赛克20mg,1次/d)+甲硝唑(0.2,3次/d)+庆大霉素针(8万U,3次/d,,口服)的两周治疗,一月后内镜下复查快速尿素酶试验(胃窦、胃体两点)。结果左氧氟沙星组Hp清除率为74.1%(83/112),甲硝唑组44.55%(45/101),两组Hp清除率比较有显著性差异有统计学意义(P<0.05)。结论质子泵抑制剂(咯赛克20mg,1次/d)+左氧氟沙星胶囊(0.2,3次/d)+呋喃唑酮(0.1,2次/d)杀菌率高,不良反应小,所以建议作为继克拉霉素组合之后的二线首选组合。

Objective To analyse and compare the curative effect to 213 patients infected by helicobaeter palori （ Hp ） that were unsuccessful treated by Amoxieillin and Clarithromyein that could be the better program. Methods The patienrs were divided into 2 groups, one receiued Omeprazole losee, Levofloxacin, Furazolidone for two weeks, the other reeeiued of Omeprazole losec, Metronidazole Tablets , Gentamycin Sulfate for two weeks. A Months later, all the patients examined Hp by the electron coronoscope. Results The Hp of 74. 1% patients were eraticated in the Levofloxaein group,and the counterpart were only 44. 55%. The statistics result show the signifieent diffirenee between the two groups （ P 〈 0. 05 and 0. 01 ） Conclusion The effect of Omeprazole losee, Levofloxaein, Furazolidone to the Hp was beffer than the Omeprazole losec, Metronidazole, Gentamycin Sulfate, so we sugest it was using Amoxicillin and Clarithromycin.