胃苏颗粒治疗消化性溃疡的临床疗效及其机制探讨

Study on the effect and mechanism of weisu granule in peptic ulcer

目的探讨胃苏颗粒配合常规疗法治疗消化性溃疡(PU)的临床疗效及其作用机制。方法106例消化性溃疡患者随机分为联用胃苏颗粒组和常规疗法组各53例。治疗4周后胃镜下观察溃疡愈合情况,并根据临床症状统计临床有效率。逆转录-多聚酶链反应(RT-PCR)检测乳癌相关肽(PS2)、肠三叶因子(ITF)基因表达变化,并同时检测氨基己糖及磷脂含量。结果胃苏颗粒组愈合率为67.92%,常规疗法组为52.83%,差异有统计学意义(P<0.05)。治疗后治疗组PS2、ITF基因表达明显强于对照组(P<0.05),氨基己糖及磷脂含量亦明显高于对照组(P<0.05)。结论在常规疗法的基础上联用胃苏颗粒治疗消化性溃疡能明显提高临床疗效,这与胃苏颗粒能明显提高PS2和ITF的表达,增加氨基己糖及磷脂含量,进而影响胃黏膜疏水性,防止溃疡的产生和复发有关。

Objective To observe the effects of treatment with Weisu granule combined routine methods in peptic ulcer（PU） and research the mechanism of action. Methods 106 patients with PU were divided into two groups randomly. We observed the effects of treatment by gastroscope and clinical symptom. Expression of PS2 and ITF was determined with RT-PCR, and the determination of contents of aninohexose and phosphatide were carried out. Results The combined group＇ s effective rate is 67. 92% ,routine methods group is 52. 83%. Difference is apparent（P 〈 0. 05 ）. The expression of PS2 and ITF were significantly higher in combined group than routine treatment （ P 〈 0. 05 ）, and the levels of aninohexose and phosphatide were significantly higher in combined group than routine treatment too （ P 〈 0. 05 ）. Conclusion On the basis of routine treatment combined with Weisu granule can heighten the curative effect in PU. It＇ s concerned with that Weisu granule could elevated markedly expression of PS2 and ITF, increased the levels of aninohexose and phosphatide , and influenced on bydrophobicity of gastric mucosa to prevent the occurrence and relapse of ulceration.