氯膦酸二钠治疗非小细胞肺癌骨转移疼痛的疗效观察

Clinical observation of disodium clodronate on pain relieve in skeletal metastases of non-small cell lang cancer

目的观察氯膦酸二钠对非小细胞肺癌骨转移的止痛效果。方法54名患者分为两组:治疗组为氯膦酸二钠联合化疗组,对照组为单纯化疗组。结果两组止痛有效率分别为77.78%(21/27)(联合化疗组),51.85%(14/27)(单纯化疗组),有显著差异(P<0.05)。结论氯膦酸二钠治疗非小细胞肺癌骨转移性疼痛安全且效果显著。

Objective To abserve the aeesodyne effect of disodium clodronate on skeletal metastases of non-small cell lang cancer. Methods 54 patients were divided into two groups,treatment group：treated with disodium clodronate combined chemotherapy （n = 27） and control group：treated with regular chemotherapy（ n = 27）. Results The effictive rate of acesodyne effect in treatment group, control group were 77.78% （21/27）, 51.85% （ 14/27）, showing a significant diffirent （ P 〈 0. 05 ）. Conclusion The treatment of disodium clodronate on pain relieve in skeletal metastases of non-small cell lang cancer is effictive and safe.