摘要
目的通过免疫组化的方法研究狼疮肾炎肾活检组织中α-SMA(α-平滑肌动蛋白)的表达,从而探讨细胞转分化为肌成纤维细胞,表达α-SMA在LN肾组织损伤中的作用。方法采用免疫组化的方法对26例狼疮肾炎患者肾活检组织中α-SMA的表达水平,并与5例正常肾组织比较。结论细胞转分化为肌成纤维细胞,表达α-SMA在狼疮肾炎的发展及肾损伤进入慢性化、纤维化阶段起重要作用。
Objective To observe the expression of α- SMA in renal tissue of 26 patients with lupus nephritis （LN） including LN type （ Ⅱ,Ⅲ, Ⅳ,Ⅴ ） ,To investigate the significance of transdifferentiation, the expression of α- Smooth muscle actin （α- SMA ） in Lupus nephritis. Method The expression of α- SMA in renal biopsy specimens of 26 patients with LN were detected by immunohistochemical stains and semiquantitative by using percentage rate of positive area, comparing with 5 cases of normal kidney tissues. Conclusion Transdifferentiation and the espression of α-SMA play a siginifieant role in the progression of the chronic injury and fibrosis in LN.
出处
《皮肤病与性病》
2008年第4期1-3,共3页
Dermatology and Venereology
