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抗生素诱导的细胞感受态与肺炎链球菌的耐药性 被引量：4

Antibiotic stress induced competence and the drug resistance in Streptococcus pneumoniae
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摘要 针对环境中的压力,细菌会采取不同的响应以维持自身的稳定。某些抗生素能够诱导肺炎链球菌转变为感受态细胞,提高细胞转化率,从而产生更适宜生存的耐药突变株。本文根据近年来有关感受态的研究,重点阐述肺炎链球菌中抗生素诱导的感受态与耐药性之间的关系。 Bacteria took different general responses to stress conditions for survival. In response to antibiotic stress, Streptococcus pneumoniae used competence as a fitness-enhancing strategy. Transformation contributed the genetic plasticity and played a central role in the pathogen adaptive resistance to the antibiotic therapy. This review focused on the relationship between competence and bacterial antibiotic resistance.
作者 齐晓丹 陈代杰 戈梅
机构地区 上海医药工业研究院 上海来益生物药物研发中心
出处 《中国抗生素杂志》 CAS CSCD 北大核心 2008年第12期710-713,720,共5页 Chinese Journal of Antibiotics
关键词 肺炎链球菌 抗生素 感受态 转化 耐药性 Streptococcus pneumoniae Antibiotics Competence Transformation Resistance
分类号 R378.12 [医药卫生—病原生物学]
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参考文献25

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二级参考文献11

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中国抗生素杂志
2008年 第12期

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