强化免疫对HBVDNA阳性孕妇母婴阻断的应用观察

To Discuss The Effect on the Interruption of HBV Matemal-infantile Intrauterine Infection with the Strengthening Immunity

目的:探索乙型肝炎病毒(HBV)母婴阻断的有效途径。方法:就我院分娩的106例HBVDNA阳性的孕妇,临床采用随机分组的方式,分为观察组和对照组。观察组:母体阻断,自妊娠20周开始注射高效价乙肝免疫球蛋白(HBIG)200 IU,每月1次,共5次;新生儿阻断,基因重组乙肝疫苗(HBVac)于出生后的0、1、2、12个月龄各10μg肌肉注射,出生后即刻肌注HBIG 200 IU。对照组:母体阻断,自妊娠28周开始注射HBIG 200 IU,每月1次,共3次;新生儿阻断,HBVac 10μg于出生后的0、1、6个月龄肌肉注射,出生后即刻肌注HBIG 200 IU。结果:两组新生儿宫内感染率12.5%和28.0%;慢性感染率5.4%和18.0%;免疫失败率3.6%和16.0%;免疫成功率96.4%和84.0%。结论:强化免疫是阻断HBVDNA阳性母婴传播的有效方法。

Objective： To investigate the effect method at the interrulption of HBV maternal- infantile intrauterine infection. Methods：Pregnancy woman were divided into two group s with HbsAg and HBVDNA po s itive or not. A group adopt the method of the strenthening immunty. Maternal stop： Passive immunity the pregnant woman injects hepatitis B immunogolobulin（HBIG）200 IU/M in 5 months of gestation, total 5 times; the infant was adopted by the consociation immunity metho d. Active immunity： hepatitis B vaccine（HBVac）was injected 10μg after the birth immediately, and 0, 1, 2, 12, month each 10μg subcutaneous inject;Passive immunity 200 IU of HBIC, after the birth immediately the muscle injection. B group： It was adopted the standard interruption of immunity method. Results：A, B groups infant intrauterine infection rate distinguish to 12.5 %, 28.0 % ; Chronic infection distinguishes to 5.4 %, 18.0 % ; Immunity failure rate 3.6 % and 16 % ; Immunity success rate 96.4%and 84.0 %. Conclusions： Strengthening immunity was an effctive method for interruption of HBV maternal- infantile intrauterine infection.