慢性阻塞性肺疾病患者血清视黄醇结合蛋白4水平及其与营养状况关系

Serum Retinol Binding Protein-4 Level in Patients with Chronic Obstructive Pulmonary Disease and its Rela-tionship to Nutritional Status

目的了解慢性阻塞性肺疾病(COPD)患者血清视黄醇结合蛋白4(RBP-4)水平及其与营养状况的关系,探讨其临床意义。方法采用酶联免疫吸附测定法(ELISA)检测62例COPD稳定期患者和20例健康对照者血清RBP-4水平,分析其相关因素。结果COPD组血清RBP-4水平显著低于健康对照组(P<0.01);其中COPD营养不良组降低更显著(P<0.01);COPD营养正常组较健康对照组也显著降低(P<0.01)。多元逐步回归分析表明,体质指数(BMI)和上臂肌围(MAMC)是血清RBP-4的独立相关因素。结论COPD稳定期患者血清RBP-4水平下降,营养状况越差降低越显著;营养正常的COPD患者血清RBP-4水平亦降低,提示这种改变并非均由营养不良引起,可能与疾病本身有关。

Objective To determine the serum retinol binding protein-4 level in patients with chronic obstructive pulmonary disease （COPD） and investigate its relationship to nutritional status and its clinical significance. Methods The serum retinol binding protein-4 level in 62 stable COPD patients and 20 healthy controls was measured by enzyme-linked immunosorbent assay （ELISA）. Correlated factors of serum retinol binding protein-4 were analyzed. Results The resum retinol binding protein-4 level was significantly lower in COPD patients than in the healthy controls （p 〈 0.01 ）, especially lower in COPD patients with malnutrition （P 〈 0.01 ）. The serum retinol binding protein-4 level in COPD patients without malnutrition was still significantly lower than in the healthy controls（P 〈 0.01 ）. In a multiple stepwise regression analysis, body mass index （BMI） and mid-upper ann muscle circumference （MAMC） were independent influencing factors of RBP-4. Conclusion The serum RBP-4 level in stable COPD patients is significantly lower,especially in patients with malnutrition. The serum RBP-4 level still significantly decreases in COPD patients without malnutrition. It suggests that this change is not completely due to malnutrition and may be associated with COPD.