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基底细胞样型乳腺癌形态表现及其临床病理特点 被引量：2

The Morphological and Clinical Features of Basal-like Subtype of Invasive Breast Carcinoma
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摘要 目的观察基底细胞样型乳腺癌形态特点,探讨基底细胞/肌上皮标记物表达与临床病理的关系。方法对84例组织学分级为Ⅱ、Ⅲ级的乳腺癌进行免疫组化染色,并分为5组:A组(ER+/C-erbB-2-),B组(ER+/C-erbB-2+),C组(ER-/C-erbB-2+),D组[ER-/C-erbB-2-且表达至少一种基底细胞和(或)肌上皮标记物],E组(ER-/C-erbB-2-且不表达基底细胞和肌上皮标记物)。对比观察D组与其它4组形态学差异,同时观察A、B、C3组基底细胞标记阳性与阴性病例间形态上的差异。结果基底细胞样型乳腺癌形态学表现:癌细胞弥漫分布,可被纤维分隔,有多少不等的淋巴细胞浸润,中央常见大片瘢痕状无细胞区。细胞异型性明显,胞核大且多呈空泡样,有大核仁。结论基底细胞样型乳腺癌形态学表现异型性明显。 Objective To summarize the morphological features of based-like subtype of invasive breast carcinoma （BLSIBC）, and study the relation between markers expressing and clinical pathology. Methods Immunohistochemistry was pefformed in 84 cases of breast carcinoma with grade Ⅱ and Ⅲ ,and five groups are classified： group A （ER＋/C-erbB-2-） ,group B （ER＋/C-erbB-2＋）,group C （ER-/C-erbB-2＋）, group D （ER-/C-erbB-2 and expressing at least one kind of basal cell or myoepithelium markers,group E （ER-/C-erbB-2- and not express- ing any kind of basal cell or myoepithelium markers）. The differences in microscopic features are compared and summarized between group D and other four groups, and between the cases with CK5/6＋ and CK5/6-. Results the morphological features of BLSIBC are summarized as followings： With marked pleomorphism, carcinoma cells have large karyons and their nucleoli are large and spumescent. Separated by fibrous septa, diffuse carcinoma ceils are surrounded by sparse tumor infiltrating lymphocytes, and large scarring areas without cells are seen. Conclusion The morphological features of BLSIBC possess marked pleomorphism, but basal cell or myoepithelium markers are independent of Malignant degrees in non-BLSIBC.
作者 常筱颖 李丹 杨向红
机构地区 中国医科大学附属盛京医院病理科
出处 《中国医科大学学报》 CAS CSCD 北大核心 2008年第6期800-801,807,共3页 Journal of China Medical University
关键词 乳腺癌 基底细胞样型乳腺癌 免疫组化方法 breast carcinoma basal-like subtype of invasive breast carcinoma immunohistochemistry
分类号 R361.3 [医药卫生—病理学] R737.9 [医药卫生—肿瘤]
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参考文献8

  • 1SOTIRIOU C,NEO SY, MCSHANE LM,et al. Breast cancer classification and prognosis based on gene expression profiles from a popu lation-based study [ J ]. Proc Natl Acad Sci USA, 2003,100 (18) 10393-10398.
  • 2杨光之,皋岚湘,丁华野.乳腺基底细胞样癌[J].诊断病理学杂志,2007,14(4):241-244. 被引量：24
  • 3皋岚湘,杨光之,丁华野,李琳.基底细胞样型浸润性乳腺癌病理形态观察[J].中华病理学杂志,2008,37(2):83-87. 被引量：36
  • 4TAVASSOLI FA, DEVILEE P. World Health Organization classification of tumours [J].Pathology and geneties of tumours of the breast and female genital organs Lyon: IAPC Press, 2003:13-59.
  • 5LAKLAN SR, VAN DE VIJVER MJ, et al. The pathology of familial breast cancer: predictive value of immunobistochemical markers estrogen receptor,HER-2,and p53 in patients with mutations in BRCA1 and BRCA2 [J]. J Clin Oncol,2002,20(9) : 2310-2318.
  • 6MATOS I, DUFLOTH R, ALVARENGA M, et al. p63, cytokeratin 5, and Pcadherin: three molecular markers to distinguish basal phenotype in breast carcinomas [J]. Virchows Arch,2005,18 (10): 1321-1328.
  • 7ALLRED DC,HARVEY JM,BERARDO M,et al. Prognostic and predictive factors in breast cancer by immunohistocbemical analysis [J]. Mod Pathol, 1998,11 (2) : 155-168.
  • 8VINCENT-SALOMON A, GRUEL N, LUCCHESI C, et al. Identification of typical medullary breast carcinoma as a genomic sub-group of basal-like carcinoma, a heterogeneous new entity [J ], Breast Cancer Res, 2007,9 : R24.

二级参考文献46

  • 1步宏,郑杰.美国临床肿瘤学会/美国病理学医师学院乳腺癌HER2检测指南简介[J].中华病理学杂志,2007,36(7):496-497. 被引量：24
  • 2Matos I, Dufloth R, Alvarenga M, et al. p63, cytokeratin 5, and P-cadherin : three molecular markers to distinguish basal phenotype in breast carcinomas. Virchows Arch, 2005, 447(4):688-694.
  • 3Finak G, Sadekova S, Pepin F, et al. Gene expression signatures of morphologically normal breast tissue identify basal-like tumors. Breast Cancer Res, 2006, 8(5) :R58.
  • 4Perou CM, Sφrlie T, Eisen MB, et al. Molecular portraits of human breast tumours. Nature, 2000, 406(6797) :747-752.
  • 5Sφrlie T, Perou CM, Tibshirani R, et al. Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc Nail Aead Sci U S A, 2001, 98(19) :10869-10874.
  • 6Sφrlie T, Tibshirani R, Parker J, et al. Repeated observation of breast tumor subtypes in independent gene expression data sets. Proc Nail Acad Sci U S A, 2003, 100(14):8418-8423.
  • 7Sotiriou C, Neo SY, McShane LM, et al. Breast cancer classification and prognosis based on gene expression profiles from a population-based study. Proc Natl Acad Sci U S A, 2003,100(18):10393-10398.
  • 8Nielsen TO, Hsu FD, Jensen K, et al. Immunohistochemical and clinical characterization of the basal-like subtype of invasive breast carcinoma. Clin Cancer Res, 2004, 10(16) :5367-5374.
  • 9Fulford LG, Easton DF, Reis-Filho JS, et al. Specific morphological features predictive for the basal phenotype in grade 3 invasive ductal carcinoma of breast. Histopathology, 2006,49(1):22-34.
  • 10Reis-Filho JS, Milanezi F, Steele D, et al. Metaplastic breast carcinomas are basal-like tumours. Histopathology, 2006, 49(1):10-21.

共引文献55

同被引文献36

  • 1杨光之,皋岚湘,丁华野.乳腺基底细胞样癌[J].诊断病理学杂志,2007,14(4):241-244. 被引量：24
  • 2KREIKE B,VAN KOUWENHOVE M,HORLINGS H,et al.Gene expression profiling mad histopathological characterization of triple-negative/basal-like breast carcinomas[J].Breast Cancer Res,2007,9(5):R65.
  • 3SIZ1OPIKOU K P,COBLEIGH M.The basal subtype of breast carcinomas may represent the group of breast tumors that could benefit from EGFR-targeted therapies [ J ].Breast,2007,16(1):104-107.
  • 4ANDERSON W F,MATSUNO R.Breast cancer heterogeneity:a mixture of at least two main types? [ J].J Natl Cancer Inst,2006,98(14):948-951.
  • 5PEROU C M,SORLIE T,EISEN M B,et al.Molecular portraits of human breast tumours [ J ].Nature,2000,406(6797):747-752.
  • 6SORLIE T,PEROU A M,TIBSHIRANI R,et al.Gene expres-sion patterns of breast carcinomas distinguish tumor subclasses with clinical implications[J].Proc Natl Acad Sci U S A,2001,98(19):10869-10874.
  • 7NIELSEN T O,HSU F D,JENSEN K,et al.Immunohistochemical and clinical characterization of the basal-like subtype of invasive breast carcinoma[ J ].Clin Cancer Res,2004,10(16):5367-5374.
  • 8VENKITARAMAN R.Triple-negative/basal-hke breast canc-er:clinical,pathologic and molecular features[ J].Expert Rev Anticancer Ther,2012,10(2):199-207.
  • 9RAKHA E A,REIS FILHO J S,ELLIS I O.Basal-like breast cancer:a critical review[J].J Clin Oncol,2008,26(15):2568-2581.
  • 10RODRIQUEZ PINILLA S M,SARRI0 D,HONRADO E,et al.Prognostic significance of basal-like Phenotype and fascin expres-sion in node-negative invasive breast carcinomas [ J].Clin Cancer tles,2006,12(5):1533-1539.

引证文献2

二级引证文献5

中国医科大学学报
2008年 第6期

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