鼻型NK／T细胞淋巴瘤61例预后因素分析

Prognostic analysis of 61 cases of nasal type NK/T cell lymphoma

目的探讨鼻型NK／T细胞淋巴瘤（NKTCL）的临床特点和预后因素。方法回顾性分析61例鼻型NKTCL患者的临床资料并进行随访。详细的临床特点及实验室检查结果均纳入单因素分析，单因素分析中有统计学意义的指标纳入多因素分析。结果单因素分析显示，AnnArbor分期、PS评分、IPI、B症状、结外侵犯数、LDH及β2-MG水平与鼻型NKTCL患者的生存期有关。多因素分析显示，PS评分、AnnArbor分期、LDH及β2-MG水平为生存期的独立影响因素。结论PS评分、AnnArbor分期、LDH及β2-MG水平为鼻型NKTCL预后的独立影响因素。

Objective To investigate the clinical features and prognostic factors of nasal type NK/T cell lymphoma （NKTCL）. Methods Records of 61 patients with pathologically confirmed nasal type NKTCL were reviewed.Detailed clinical and laboratory data were included in univariate analysis, and statistically significant factors in univariate analysis were then included in multivariate analysis. Results In univariate analysis, Ann Arbor stage, performance status, IPI, number of extra-lymphatic site, B symptoms, LDH and β2-MG level, were found to be the prognostic factors associated with time to overall survival in nasal type NKTCL. In multivariate analysis, Ann Arbor stage,performance status, LDH and β2-MG level were independent prognostic factors of overall survival. Conclusion Ann Arbor stage, performance status, LDH and β2-MG level were demonstrated as independent prognostic factors of the overall survival in nasal type NKTCL.