原发性巨球蛋白血症15例

Clinical analysis of 15 patients with Waldenstrom＇ s macroglobulinemia

目的探讨原发性巨球蛋白血症（WM）的临床特点。方法回顾性分析15例患者临床表现、免疫表型及治疗。结果3例完全缓解（CR），9例部分缓解（PR），7例生存，病程最长达79个月。结论WM传统的诊断方法不够完善，免疫表型能够更进一步明确诊断。在治疗方面，WM是不能治愈性疾病，但经积极治疗生存期可延长，应考虑化疗并血浆置换联合治疗。

Objective To investigate the diagnosis and treatment of Waldenstrom＇s macroglobulinemia （WM）. Methods The clinical information of 15 patients with WM were analyzed retrospectively. Results 3 cases had achieved complete response （CR）. 9 cases had achieved partial response （PR）. 7 cases remained alive, one of them lived beyond 79 months. Conclusion The traditional diagnosis of WM is not enough, and immunophenotype described for WM diagnosis is more important. WM is an incurable disease. Treatment with plasmapheresis and chemotheraov appears highly effective and safe for WM.