豨莶草水煎粉剂对小鼠肺毒性研究

An experimental study on pulmonary toxicity water extracts of Siegesbeckia pubescens on mice

目的:观察豨莶草水煎粉剂不同剂量连续灌胃给药与停药2周后,对小鼠肺脏的毒性作用。方法:昆明种小鼠随机分为4组:正常组,豨莶草水煎粉剂不同剂量(3.01,1.0,0.3 g.kg-1)组,每组40只。分别于7,14,21 d与停药2周后每组处理10只小鼠,取肺组织计算脏器指数及进行病理切片检查。结果:豨莶草水煎粉剂3.0 g.kg-1剂量组14,21 d肺指数有增高趋势,肺组织病理变化明显。停药2周后,肺毒性变化消失。结论:豨莶草水煎粉剂对小鼠肺脏有一定毒性,其毒性是可逆的。

Objective： The pulmonary toxicity of water extract of Siegesbeckia pubescens has been studied an mice following subchronic oral administration route. Method： Mice were randomly grouped and administered with the water extract of S. pubescens at dosages of 3.0,1.0,0. 3 g · kg^-1 and saline respectively, l0 mice of each group were sacrificed on the day of 7 th, 14 th, 21 th, and 2 weeks after stopping administration, histological changes of the lung were examined. Result： The water extract of S. pubescens at dosage of 3.0 g · kg^-1 increased the lung index on the of day 14 th and 21 th, significant histopathologieal damages were observed. The histopathological changes were disappeared after stopping administration for 2 weeks. Conclusion： The water extract of S. pubescens has a pulmonary toxic effect on mice, and the toxic effect is reversible.