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DNMT3B-283SNP与胃癌易感性的关联分析 被引量：1

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摘要 目的:探讨DNMT3B基因-283T>C单核苷酸多态性与胃癌易感性的关系。方法:提取外周血基因组DNA,采用PCR-RFLP结合DNA测序技术检测DNMT3B基因-283T>C单核苷酸多态性。结果:携带DNMT3BTT等位基因的个体与对照组相比,其患胃癌的易感性明显升高(P=0.017,OR=1.46,95%CI:1.07-2.01)。结论:DNMT3B基因-283T>C多态性可能与胃癌的易感性有关联。
作者 刘东声
机构地区 南京鼓楼医院集团宿迁市人民医院
出处 《内蒙古中医药》 2008年第11期187-188,共2页 Inner Mongolia Journal of Traditional Chinese Medicine
关键词 DNA甲基转移酶3B 胃癌 单核苷酸多态性
分类号 R735.2 [医药卫生—肿瘤]
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  • 1左石,罗剑,刘民锋,徐立宁,董泾青,郭伟,邹声泉.DNA甲基转移酶1、3b基因共下调对人胆管癌细胞生长的抑制效应[J].中华实验外科杂志,2006,23(8):912-915. 被引量：12
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内蒙古中医药
2008年 第11期

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