氯诺昔康超前镇痛对全髋关节置换术后芬太尼镇痛的影响

CLINICAL RESEARCH ON THE INFLUENCE OF LORNOXICAM'S PREEMPTIVE ANALGESIA TO RELIEVING PAIN OF FENTANYL POST-REPLACEMENT OF TOTAL HIP

目的:观察氯诺昔康超前镇痛对全髋关节置换术后芬太尼镇痛效果的影响。方法:将60例患者随机分成观察组和对照组,观察组手术切皮前15min静脉注射氯诺昔康16mg,对照组静脉注射等容量生理盐水。两组术后均采用芬太尼静脉自控镇痛。于术后4h、8h、12h、24h、48h时采用视觉模拟评分(VAS)法对两组患者进行镇痛评分,并记录不良反应的发生情况。结果:两组镇痛效果相似,VAS评分值差异无统计学意义(P>0.05),观察组48h内芬太尼用药量明显小于对照组(P<0.05),恶心、呕吐的发生率低于对照组(P<0.05)。结论:氯诺昔康超前镇痛能明显减少术后静脉自控镇痛芬太尼的用药量及不良反应。

Objective:To observe the influence of Lornoxicam's preemptive analgesia to the effect of fentanyl's relieving pain post-replacement of total hip.Methods:60 cases of patients for replacement of total hip were randomly divided into two groups,observe group(Lornoxicam,16mg,were given by intravenous injection 15 min before skin cut in operation)and control group(the same volume of normal saline were added).Both of they were taken for patient-controlled analgesia with fentanyl post-operation.On points of 4 hours,8 hours,12 hours,24 hours and 48 hours post-operation they were made score of analgesia with visual analog scale(VAS),and informations of adverse effect on them were recorded.Results:In two groups,there had similar effect on analgesia,there had not statistically significant on discrepancy of VAS' scores(P> 0.05).In observe group,drug consumption of fentanyl during 48 hours was obviously infra to that of control group(P<0.05),the incidence rates of nausea and vomit were fewer than those of control(P<0.05).Conclusion:Lornoxicam' s preemptive analgesia could obviously reduce drug consumption of fentanyl for patient-controlled analgesia through vein and adverse effects post-operation.