PLA2G4C基因多态性与精神分裂症关系的病例对照研究

Case control study on association between polymorphism of PLA2G4C and schizophrenia

目的探讨中国北方汉族人群PLA2G4C rs1549637位点基因多态性与精神分裂症的关系。方法采用聚合酶链式反应(PCR)和连接酶检测(LDR)的方法,在中国北方汉族403例精神分裂症患者和400例健康对照者的血液样本中检测PLA2G4C基因上的rs1549637位点的基因型。结果PLA2G4C基因上的rs1549637位点基因多态性与精神分裂症无统计学关联(P>0.05),该位点的基因型频率与等位基因频率与精神分裂症的临床症状无关联(P>0.05)。结论PLA2G4C基因可能不是精神分裂症的易感基因。

Objective To investigate the genetic association between PLA2G4C gene polymorphism and schizophrenia in the North Han Chinese. Methods The method of PCR-based ligase detection reaction （PCR-LI）R） was applied to genotype rs1549637 in PLA2G4C gene among 403 patients with schizophrenia and 400 healthy people. Results The polymorphism of rs1549637 in PLA2G4C gene was not associated with schizophrenia or clinic symptoms of schizophrenia （ P 〉 0.05）. Conclusions The PLA2G4C gene may not be a susceptible gene for schizophrenia.